SMTP 550
In short: The mail server rejects the e-mail permanently (for example recipient does not exist).
In more detail: 550 belongs to the permanent errors (5xx).
In Depth
Possible causes
- Recipient address wrong.
- Sender classified as spam or SPF/DKIM missing.
- Mailbox full or blocked.
Solutions
- Check the address.
- Set up the sender domain with SPF, DKIM and DMARC.
- Check the entry if on a blocklist.
See also: SMTP, Spam E-mail, DNS